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Biographical Info
Dr. Angélique Bordey holds the rank of Associate Professor of Neuroscience. Dr. Bordey is an active participant in teaching and training of graduate and medical students at Yale School of Medicine. Dr. Bordey is the Editor-in-Chief of the journal Frontiers in Neurogenesis and an executive Editor of the journal Neuropharmacology. She has served as an Ad Hoc member on several study sections. She has organized several national and international symposiums, and is frequently an invited speaker. Finally, she is a McKnight awardee and holds several grant fundings.
Education & Training
Honors & Recognition
Cathryn Kubera Keating, Ph.D., Postdoctoral Fellow
Education:
2002-2008 University of Pennsylvania, Ph.D. (Neuroscience)
1998-2002 Cornell University, B.S. (Cell & Molecular Biology)
Summary:
My research in the Bordey lab focuses on glutamatergic signaling in postnatal cerebellum development. For about two weeks after birth, granule cell precursors (GCPs) in the external germinal layer (EGL) of the cerebellum continue proliferating until they exit the cell cycle and migrate along Bergmann glia processes to the internal granular layer, where they are integrated into the network. During their time in the EGL, GCPs acquire expression of several types of glutamate receptors, including mGluR5 and kainate receptor GluK2. These receptors have been linked to developmental disorders in humans like schizophrenia and autism, respectively. The goals of my project include (1) determining the function of mGluR5 or GluK2 activation on GCP development and (2) identifying the source of glutamate release in the EGL.
David M. Feliciano, Ph.D. Postdoctoral Fellow
Education:
2004-2008 State University of New York at Buffalo, PhD (Pharmacology)
Summary: Neural stem cells must efficiently and proficiently integrate extracellular and intracellular signals to properly generate the nervous system. An inbalance in these signals can lead to aberrant proliferation as seen in familial inherited CNS tumors or precocious differentiation as seen in certain malformations of cortical development. My goal is to determine the molecular mechanisms by which neural stem cells make these decisions. Tuberous Sclerosis Complex (TSC) is a neurocutaneous disorder characterized by a predisposition to tumor formation in the subventricular zone and a malformed cortex which may be responsible for seizures in these patients. Using unique targeting approaches to remove TSC associated genes from populations of neural stem cells I have generated distinct mouse models of TSC. For example, we used in utero electroporation to manipulate radial glia during embryonic development thereby generating a focal model of cortical tubers. I hope to further our understanding of the etiology and to generate more effective therapeutic approaches for the treatment of TSC and similar neurocutaneous diseases.
Publication List:
Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A Postnatal neurogenesis generates heterotopias, olfactory micronodules, and cortical infiltration following single-cell Tsc1 deletion Human Molecular Genetics November 7 2011
Feliciano D, Bordey A Mouse Model of Tuberous Sclerosis Complex Med Sci (Paris). 2011 Mar;27(3):328-30.
Feliciano DM, Su T, Lopez J, Platel JC, Bordey A Single-cell Tsc1 knockout during murine corticogenesis generates tuber-like lesions and reduces seizure threshold without astrogliosis Journal of Clinical Investigation J Clin Invest. 2011 Apr 1;121(4):1596-607
Feliciano DM and Edelman AM Repression of Ca2+/calmodulin-dependent protein kinase (CaMK)IV signaling accelerates retinoic acid (RA)-induced differentiation of human neuroblastoma cells J Biol Chem. 2009 Aug 13
Feliciano DM and Edelman AM CaMKIV regulates survival/proliferation of neuroblastoma cells The FASEB Journal, 2008
Nathaniel Hartman, Ph.D. Posdoctoral Fellow
Education:
PhD, Wesleyan University, 2010
BA, Clark University, 2001
Summary:
Adult neurogenesis is an ongoing process in the subventricular zone of the mammalian brain. My aim is to understand the molecular mechanisms that coordinate the maintenance and proliferation of neural stem cells in this niche.
Publications list:
Hartman NW, Carpentino JE, LaMonica K, Mor DE, Naegele JR, Grabel L. (2010) CXCL12-Mediated Guidance of Migrating Embryonic Stem Cell-Derived Neural Progenitors Transplanted into the Hippocampus. PLoS One, in press.
Hartman NW, Grabel L, Naegele JR (2010) Migration of Transplanted Neural Stem Cells in Experimental Models of Neurodegnereative Diseases. in: Stem Cells & Regenerative Medicine. Springer Press, Appasani K and Appasani R. eds. 315-336. Review.
Ammon N, Hartman N, Grabel L (2010) Directing differentiation of embryonic stem cells into distinct neuronal subtypes. In: Perspectives of Stem Cells: From tools for studying mechanisms of neuronal differentiation towards therapy. Springer Press, Ulrich, H ed. 97-115. Review.
Carpentino JE, Hartman NW, Grabel LB, Naegele JR (2008) Region-specific differentiation of embryonic stem cell-derived neural progenitor transplants into the adult mouse hippocampus following seizures. J Neurosci Res. Feb 15; 86(3): 512-24.
Carlos A. Lafourcade, Ph.D. Postdoctoral Associate
Education:
2004-2009 University of Maryland
Summary: I study the mechanisms by which neurons regulate inhibition in the brain, and the disorders that arise when this process is affected. My PhD thesis involved studying the effects of endocannabinoids on long term inhibition in the hippocampus. Currently, I am working on the Granule cell layer of the olfactory bulb, studying the effects on inhibition after disrupting a pathway that is relevant to the Tuberous Sclerosis Complex.
Publications list: Presynaptic mechanisms of endocannabinoid - mediated long term depression in the hippocampus. Lafourcade CA. J Neurophysiol, Oct; 102(4):2009-12.
Novel mGluR- and CB1R-independent suppression of GABA release caused by a preparation of the group I metabotropic glutamate receptor agonist, DHPG. Lafourcade C., Zhang L, Alger B –PLoS One Jul 1; 4(7), 2009
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels. Ryan D, Drysdale AJ, Lafourcade C, Pertwee RG, and Platt B. J Neurosci 29: 2053-2063, 2009.
Distinctions among GABAA and GABAB responses revealed by calcium channel antagonists, cannabinoids, opioids, and synaptic plasticity in rat hippocampus. Lafourcade CA, and Alger BE. Psychopharmacology (Berl) 198: 539-549, 2008.
Human erythroid cells are affected by aluminium. Alteration of membrane band 3 protein. Vittori D, Garbossa G, Lafourcade C, Perez G, and Nesse A. Biochim Biophys Acta 1558: 142-150, 2002.
Characterisation of cAMP-dependent protein kinase isoforms in the brain of the crab Chasmagnathus. Locatelli F, Lafourcade C, Maldonado H, and Romano A. J Comp Physiol B 171: 33-40, 2001.
Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus. Freudenthal R, Locatelli F, Hermitte G, Maldonado H, Lafourcade C, Delorenzi A, and Romano A. Neurosci Lett 242: 143-146, 1998.
Rat urinary chemiluminescence: effect of ethanol and/or hexachlorobenzene uptake. J Biolumin Chemilumin 13: 63-68, 1998. Rios de Molina MC, Suarez Lissi AM, Armesto A, Lafourcade C, and Lissi E. J Biolum. Chemilumin: 13: 63-68, 1998.
Yuri Ikeda-Matsuo, Ph.D., visiting associate professor
Education:
2001 University of Tokyo, Ph.D.
1994-1998 University of Tokyo, M.S. and D.S.
1991-1994 University of Tokyo, B.S.
Professional Experience:
2010-present Yale University, visiting associate professor
2006-present Kitasato University, associate professor
1998-2006 Kitasato University, assistant professor
Summary:
I am investigating about inflammatory mediators, which regulate neuronal death in brain ischemia and Parkinson’s disease. Although increased neurogenesis in subventricular zone after brain ischemia is well known, the mechanism and role of enhanced-neurogenesis are not elucidated yet. In the Bordey Lab, I will investigate about the mechanisms of the adult neurogenesis using Fucci mice generated by RIKEN.
Publications list:
Ikeda-Matsuo Y, Tanji H, Ota A, Hirayama Y, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin EP3 receptors. Br. J. Pharmacol., 160: 847–859 (2010).
Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. Br. J. Pharmacol., 159: 1174–1186 (2010).
Yamaguchi H, Shiraishi M, Fukami K, Tanabe A, Ikeda-Matsuo Y, Naito Y, Sasaki Y. MARCKS regulates lamellipodia formation induced by IGF-1 via association with PIP2 and b-actin at membrane microdomain. J. Cell Physiol., 220 (3): 748-755 (2009).
Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. Proc. Natl. Acad. Sci. U S A, 103(31): 11790-11795 (2006)
Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y. Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production. J. Neurochem., 94(6): 1546-1558 (2005)
Christopher Bartley, MD/PhD Candidate
Education:
2007 – Present Yale University, expected M.D. & PhD
2000 – 2004 Yale University, B.S. (MCDB – Neurobiology Concentration)
1996 – 2000 Alexander Dawson Preparatory Academy, Diploma
Summary:
I am interested in developmental single-gene disorders that disrupt the architecture and physiology of the brain. It is my hope that a better understanding of the genetic and molecular underpinnings of these disorders will lead to early interventions that partially or fully prevent the manifestation of disease.
Publications list:
Hashimoto-Torii K, Torii M, Sarkisian MR, Bartley CM et. al. “Interaction between Reelin and Notch signaling regulates neuronal miration in the cerebral cortex.” Neuron 2008 Oct 23;60(2):273-84.
Sarkisian MR, Bartley CM, Rakic P. “Trouble making the fist move: interpreting arrested neuronal migration in the cerebral cortex.” Trends Neurosci. 2008 Feb;31(2):54-61. (Review)
Sarkisian MR, Bartley CM* et. al. “MEKK4 Deficiency Results in Periventricular Heterotopia, Impaired Neuronal Migration and Abnormal Filamin Expression.” Neuron 2006 Dec 7;52(5):789-801.
Linseman DA, Bartley CM et. al. “Inactivation of the Myocyte Enhancer Factor-2 Repressor Histone Deacetylase-5 by endogenous Ca2/Calmodulin-dependent Kinase II Promotes Depolarization-mediate Cerebellar Granule Neuron Survival.” JBC 2003, 278: 41472 – 41481.
* Denotes Co-first authorship
Bordey Lab Alumni:
Jonathan Genzen, MD, Ph.D.: Postdoc
Current Position: Assistant Professor of Pathology and Laboratory Medicine at the Weill Cornell Medical College
Jean Claude Platel, Ph.D.: Postdoc
Current Position: Group Leader University of Homberg, Germany
Oliver Henschel, Ph.D: Postdoc
Anna J. Bolteus, PhD: Postdoc
Xiuxin Liu, MD, PhD: Postdoc
Current Position: Postdoc, Rakic Lab
Kathy Egan Dave, Ph.D: student, graduate
Current Position: Editor Nature Neuroscience
Benjamin J. Lacar, Ph.D.: student, graduate and postdoc
Current Position: Postdoc Gage lab, Salk Institute
Stephanie Z. Young, Ph.D.:graduate student
Doris Wang, MD, PhD: student, undergraduate